Rapid transfer ports sometimes feature systems for sterilizing incoming components using heat. Filling and Transfer Processesĭuring filling operations in an isolator, sterilized products or containers are transferred into the unit through rapid transfer ports, airlocks, or similar controlled openings. When the interior of the isolator is undergoing decontamination, the exit port must typically be sealed up until the procedure is complete. This specialized port is designed to prevent ambient air from entering the isolator enclosure by providing a steady outward flow of filtered air. Open isolators are more commonly used for aseptic procedures involving products or product components continually entering and exiting the workspace through a port. These units provide the most effective protection from airborne impurities, but can be relatively slow for production or processing work. Closed isolators are completely sealed, blocking any contaminated or unfiltered air from entering the enclosure during operation. The majority of isolators come in either a closed or open form. A light positive air pressure is maintained to prevent the entrance of contaminants from any openings, while worker activities are conducted through sealed glove assemblies. Isolators typically feature built-in air filtration systems capable of significantly lowering a particle count in an enclosed area, and their relatively compact size makes it easier to clean their interiors with gas or vapor sterilizing agents. Isolators are generally used in applications requiring a high degree of protection from external elements or contaminants, and they can also serve as alternatives to sophisticated cleanrooms. These devices usually have their own air filtration units independent of cleanroom ventilation and can provide workspaces that are some degree cleaner than the larger cleanroom itself.Īn isolator is a type of clean air device that creates an almost complete separation between a product and its production equipment, technical personnel, and surrounding work environment. In addition to cleanroom garments, curtains, and structures, clean air devices, such as transfer hoods, safety cabinets, and isolators can be used to achieve the necessary level of contaminant control. Barriers between the contamination source and the process, product, or personnel in the cleanroom can effectively shield sensitive elements. In an industrial cleanroom environment, unidirectional air flow can provide a component or process with protection from airborne contaminants, but additional measures may be required to block these types of contaminants in certain applications.
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